{"id":266,"date":"2023-08-17T09:43:59","date_gmt":"2023-08-17T00:43:59","guid":{"rendered":"https:\/\/ninomiyacl.com\/blog\/?p=266"},"modified":"2023-08-17T09:44:00","modified_gmt":"2023-08-17T00:44:00","slug":"%e8%a1%80%e6%b6%b2%e3%81%8c%e3%82%93%e3%81%ae%e6%9c%80%e6%96%b0%e6%b2%bb%e7%99%82%e6%b3%95%e3%80%80cart%e7%b4%b0%e8%83%9e%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/ninomiyacl.com\/blog\/archives\/266\/","title":{"rendered":"\u8840\u6db2\u304c\u3093\u306e\u6700\u65b0\u6cbb\u7642\u6cd5\u3000CART\u7d30\u80de\u7642\u6cd5"},"content":{"rendered":"\n

\u4eca\u65e5\u306f\u3001\u8840\u6db2\u304c\u3093\u306e\u6700\u65b0\u6cbb\u7642\u6cd5\u3000CART\u7d30\u80de\u7642\u6cd5\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u304c\u3093\u3068\u6226\u3046\u6b66\u5668\u304cCAR\uff08Chimeric Antigen Receptor, \u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53\uff09\u3068\u3044\u3046\u540d\u524d\u3067\u3001T\u7d30\u80de\u3092\u5f37\u5316\u3059\u308b\u305f\u3081\u3001\u300cCAR-T\u7d30\u80de\u7642\u6cd5\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u30012019\u5e745\u6708\u306b\u3001\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306e\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u65e5\u672c\u3067\u3082\u8a8d\u53ef\u3055\u308c\u305f\u5168\u304f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u73fe\u5728\u306f\u3001\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306e\u307b\u304b\u3001B\u7d30\u80de\u6027\u306e\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u3084\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306b\u3082\u3053\u306e\u6cbb\u7642\u6cd5\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u3001\u60a3\u8005\u3055\u3093\u81ea\u8eab\u304c\u6301\u3063\u3066\u3044\u308b\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3001T\u7d30\u80de\u3092\u8840\u6db2\u304b\u3089\u63a1\u53d6\u3057\u3066\u3001\u304c\u3093\u3068\u6226\u3046\u3088\u3046\u306b\u5f37\u5316\u3057\u3066\u4f53\u306b\u623b\u3059\u3068\u3044\u3046\u9ad8\u5ea6\u306a\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n

\u3057\u304b\u3057\u3001\u6cbb\u7642\u8cbb\u304c\u306a\u3093\u3068\uff11\u56de3000\u4e07\u5186\u8d85\u3068\u306a\u3063\u3066\u304a\u308a\u8d85\u9ad8\u984d\u3067\u3059\u3002\u60a3\u8005\u3055\u3093\u306e\u8ca0\u62c5\u306f\u9ad8\u984d\u533b\u7642\u8cbb\u52a9\u6210\u304c\u9069\u5fdc\u3055\u308c\u307e\u3059\u306e\u3067\u5b89\u5fc3\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u201c\u60a3\u8005\u3055\u3093\u81ea\u8eab\u201d\u306e\u514d\u75ab\u7d30\u80de<\/strong><\/p>\n\n\n\n

\u304c\u3093\u306f\u3001\u514d\u75ab\u7cfb\u304c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u305f\u3081\u306b\u9032\u884c\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u8840\u6db2\u764c\u306e\u767d\u8840\u75c5\u306b\u306f\u5065\u5eb7\u306a\u65b9\u306e\u514d\u75ab\u7d30\u80de\u3092\u501f\u308a\u308b\u3001\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3001\u4e00\u822c\u7684\u306b\u306f\u9aa8\u9ac4\u79fb\u690d\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u4ed6\u8005\u306e\u514d\u75ab\u3067\u3042\u308b\u305f\u3081\u3001\u79fb\u690d\u3055\u308c\u305f\u514d\u75ab\u7d30\u80de\u304c\u60a3\u8005\u3055\u3093\u306e\u4f53\u5185\u3067\u304c\u3093\u306e\u307f\u306a\u3089\u305a\u6b63\u5e38\u306a\u7d44\u7e54\u3082\u653b\u6483\u3059\u308b\u3068\u3044\u3046\u73fe\u8c61\u304c\u8d77\u304d\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306e\u514d\u75ab\u7d30\u80de\u304c\u5143\u3068\u306a\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u305d\u306e\u3088\u3046\u306a\u5fc3\u914d\u304c\u306a\u304f\u3001\u9aa8\u9ac4\u79fb\u690d\u306e\u3088\u3046\u306b\u30c9\u30ca\u30fc\u3092\u63a2\u3059\u5fc5\u8981\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u6628\u5e74\uff11\u6708\u304b\u3089\u3001\u5c90\u961c\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3067\u3082\u3001\u5c90\u961c\u770c\u5185\u3067\u521d\u3081\u3066\u3053\u306e\u6cbb\u7642\u6cd5\u304c\u958b\u59cb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u306f\u3001\u79c1\u306f\uff11\uff10\u5e74\u307b\u3069\u524d\u306b\u30a2\u30e1\u30ea\u30ab\u306b\u7559\u5b66\u3057\u3001\u3053\u306eCAR-T\u7d30\u80de\u7642\u6cd5\u306e\u57fa\u790e\u7814\u7a76\u306b\u643a\u308f\u3063\u3066\u3044\u307e\u3057\u305f\u306e\u3067\u3001\u611f\u6168\u6df1\u3044\u601d\u3044\u3067\u3059\u3002<\/p>\n\n\n\n

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs<\/a><\/h1>\n\n\n\n

<\/p>\n\n\n\n

\u305d\u308c\u3067\u306f\u3001\u3082\u3046\u5c11\u3057\u8a73\u3057\u304f\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

CART\u7d30\u80de\u7642\u6cd5\u306e\u9069\u5fdc\u3068\u306a\u308b\u60a3\u8005\u3055\u3093\u306f\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u300c\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u300d\u300c\u767d\u8840\u75c5\u300d\u300c\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u300d\u306b\u9069\u7528\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u8a73\u7d30\u306b\u898b\u305f\u5834\u5408\u3001\u305d\u306e\u4e2d\u306e\u5168\u3066\u306e\u30bf\u30a4\u30d7\u304c\u5bfe\u8c61\u3068\u306a\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u304c\u3093\u306e\u8a73\u7d30\u306a\u30bf\u30a4\u30d7\u306b\u52a0\u3048\u3001\u300c\u518d\u767a\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u308b\u300d\u300c\u96e3\u6cbb\u6027\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u70b9\u3082\u5fc5\u8981\u3067\u3059\u3002\u8a73\u3057\u304f\u306f\u3001\u4e3b\u6cbb\u533b\u306e\u5148\u751f\u306b\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

CAR-T<\/strong>\u7642\u6cd5\u306e\u6d41\u308c<\/strong><\/p>\n\n\n\n

CAR-T\u7642\u6cd5\u306e\u6d41\u308c\u3092\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

CAR-T\u7642\u6cd5\u3067\u306f\u3001\u307e\u305a\u3001\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u304b\u3089\u732e\u8840\u306e\u3088\u3046\u306b\u30d9\u30c3\u30c9\u306b\u6a2a\u306b\u306a\u3063\u305f\u72b6\u614b\u3067\u3001\u30a2\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9\u3068\u3044\u3046\u6a5f\u68b0\u3092\u4f7f\u3044\u30ea\u30f3\u30d1\u7403\u3092\u53d6\u308a\u51fa\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u53d6\u308a\u51fa\u3057\u305f\u30ea\u30f3\u30d1\u7403\u306f\u3001\u88fd\u85ac\u4f1a\u793e\u306e\u65bd\u8a2d\u3078\u9001\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u88fd\u85ac\u4f1a\u793e\u306e\u65bd\u8a2d\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u4f7f\u3063\u305f\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308a\u60a3\u8005\u3055\u3093\u306e\u30ea\u30f3\u30d1\u7403\u306bCAR\u3092\u767a\u73fe\u3055\u305b\u307e\u3059\u3002CAR\u3092\u767a\u73fe\u3057\u305f\u30ea\u30f3\u30d1\u7403\u306f\u304c\u3093\u7d30\u80de\u306e\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u6297\u539f\u3092\u7279\u7570\u7684\u306b\u8a8d\u8b58\u3057\u653b\u6483\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30ea\u30f3\u30d1\u7403\u306e\u4e2d\u306eT\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u5897\u3084\u3059\u6761\u4ef6\u4e0b\u3067\u3001CAR\u3092\u767a\u73fe\u3055\u305b\u305fT\u7d30\u80de\u3092\u5927\u91cf\u306b\u5897\u5e45\u57f9\u990a\u3057\u307e\u3059\u3002\u57f9\u990a\u306b\u306f10\u65e5\u304b\u30892\u9031\u9593\u7a0b\u5ea6\u304b\u304b\u308a\u307e\u3059\u304c\u3001\u57f9\u990a\u5f8c\u306e\u54c1\u8cea\u691c\u67fb\u306a\u3069\u3082\u3042\u308a\u3001\u5b9f\u969b\u306b\u6295\u4e0e\u306e\u6e96\u5099\u304c\u5b8c\u4e86\u3059\u308b\u306b\u306f2\u304b\u6708\u307b\u3069\u304b\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u88fd\u85ac\u4f1a\u793e\u306e\u65bd\u8a2d\u304b\u3089\u6cbb\u7642\u3059\u308b\u75c5\u9662\u3078\u5b8c\u6210\u3057\u305fCART\u7d30\u80de\u304c\u9001\u3089\u308c\u3066\u304d\u305f\u3089\u3001\u70b9\u6ef4\u306b\u3088\u308a\u60a3\u8005\u3055\u3093\u306e\u4f53\u306b\u623b\u3057\u307e\u3059\u3002CAR-T\u7d30\u80de\u3092\u60a3\u8005\u3055\u3093\u306e\u4f53\u5185\u306b\u623b\u3059\u3068\u304d\u306b\u306f\u3001\u524d\u51e6\u7f6e\u3068\u3057\u3066\u60a3\u8005\u3055\u3093\u306b\u6297\u304c\u3093\u5264\u3092\u6295\u4e0e\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4f53\u5185\u306e\u30ea\u30f3\u30d1\u7403\u3092\u6e1b\u3089\u3059\u306e\u304c\u76ee\u7684\u3067\u3059\u3002<\/p>\n\n\n\n

\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u306b\u6295\u4e0e\u3055\u308c\u308b\u3068\u3001CART\u7d30\u80de\u306f\u5168\u8eab\u3092\u56de\u3063\u3066\u3001\u304c\u3093\u7d30\u80de\u3092\u898b\u3064\u3051\u51fa\u3057\u653b\u6483\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u969b\u306b\u4f1d\u308f\u308b\u523a\u6fc0\u306b\u3088\u308a\u3001CAR-T\u7d30\u80de\u81ea\u8eab\u304c\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u5185\u3067\u5897\u6b96\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u6295\u4e0e\u306f\u4e00\u5ea6\u306e\u307f\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

CAR-T\u7642\u6cd5\u306e\u6cbb\u7642\u85ac\u306f\u3001\u6295\u4e0e\u3059\u308b\u3068\u52b9\u679c\u304c\u9577\u7d9a\u304d\u3059\u308b\u306e\u304c\u7279\u5fb4\u306e1\u3064\u3067\u3059\u3002CAR-T\u7d30\u80de\u306f\u4f53\u5185\u30671000\u500d\u307b\u3069\u306b\u5897\u3048\u3001\u3057\u304b\u3082\u534a\u5e74\u304b\u30891\u5e74\u4ee5\u4e0a\u3082\u4f53\u5185\u306b\u6b8b\u3063\u3066\u52b9\u679c\u3092\u767a\u63ee\u3057\u7d9a\u3051\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u6cbb\u7642\u52b9\u679c<\/strong><\/p>\n\n\n\n

\u6cbb\u7642\u52b9\u679c\u306f\u3001\u304c\u3093\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u304c\u3001\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u5bfe\u3059\u308b\u7c73\u56fd\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3092\u898b\u308b\u3068\u3001\u518d\u767a\u30fb\u96e3\u6cbb\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u3067\u306f\u3001\u5b8c\u5168\u5bdb\u89e3\u3092\u5f97\u3089\u308c\u305f\u60a3\u8005\u3055\u3093\u304c90\uff05\u3068\u9a5a\u7570\u7684\u306a\u6570\u5b57\u3067\u3059\u3002\u307e\u305f\u3001\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306e\u3046\u3061\u3001\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578b\uff22\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3067\u306f\u3001\u304a\u3088\u305d\uff14\u5272\uff5e\uff16\u5272\u304c\u300c\u5b8c\u5168\u5bdb\u89e3\u300d\u3068\u3044\u3046\u72b6\u614b\u306b\u81f3\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002CAR-T\u7d30\u80de\u7642\u6cd5\u304c\u767b\u5834\u3059\u308b\u4ee5\u524d\u306e\u5bdb\u89e3\u7387\u306f\uff11\u5272\u4ee5\u4e0b\u3067\u3057\u305f\u306e\u3067\u3001\u305d\u308c\u304c\uff14\uff5e\uff16\u5272\u306b\u5411\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e3b\u306a\u526f\u4f5c\u7528<\/strong><\/p>\n\n\n\n

CAR-T\u7d30\u80de\u7642\u6cd5\u3067\u306f\u3001\u901a\u5e38\u306e\u6297\u304c\u3093\u5264\u6cbb\u7642\u306e\u3088\u3046\u306a\u5614\u5410\u3084\u8131\u6bdb\u3068\u3044\u3063\u305f\u75c7\u72b6\u3068\u306f\u7570\u306a\u308b\u526f\u4f5c\u7528\u304c\u751f\u3058\u307e\u3059\u3002\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u306e\u304c\u300c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u300d\u3068\u3044\u3046\u5168\u8eab\u306e\u5f37\u3044\u708e\u75c7\u75c7\u72b6\u3067\u3059\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u306f\u6575\u3092\u5012\u3059\u305f\u3081\u306b\u514d\u75ab\u7d30\u80de\u304c\u51fa\u3059\u7269\u8cea\u3002\u514d\u75ab\u53cd\u5fdc\u306b\u5fc5\u8981\u3067\u3059\u304c\u3001\u904e\u5270\u306b\u306a\u308b\u3068\u653b\u6483\u306e\u77db\u5148\u304c\u5168\u8eab\u306e\u81d3\u5668\u3078\u3068\u5411\u304b\u3044\u3001\u547d\u306e\u5371\u967a\u304c\u751f\u3058\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u8840\u6db2\u304c\u3093\u306e\u6700\u65b0\u6cbb\u7642\u3067\u3042\u308bCART\u7d30\u80de\u7642\u6cd5\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u3057\u307e\u3057\u305f\u3002\u8840\u6db2\u764c\u306b\u9650\u3089\u305a\u3001\u3059\u3079\u3066\u306e\u764c\u306bCART\u7d30\u80de\u7642\u6cd5\u304c\u4f7f\u308f\u308c\u3001\u764c\u60a3\u8005\u3055\u3093\u306e\u4e88\u5f8c\u304c\u3088\u308a\u3088\u304f\u306a\u308b\u65e5\u304c\u6765\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n

\u4e8c\u5bae\u533b\u9662\u3000\u816b\u760d\u5185\u79d1<\/a>\u3000\u8840\u6db2\u5185\u79d1<\/a><\/p>\n\n\n\n

\"\"
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