{"id":210,"date":"2021-12-19T16:05:16","date_gmt":"2021-12-19T07:05:16","guid":{"rendered":"https:\/\/ninomiyacl.com\/blog\/?p=210"},"modified":"2021-12-19T16:05:18","modified_gmt":"2021-12-19T07:05:18","slug":"%e9%ab%98%e6%bf%83%e5%ba%a6%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3c%e7%82%b9%e6%bb%b4%e3%81%a8%e4%b9%b3%e7%99%8c%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/ninomiyacl.com\/blog\/archives\/210\/","title":{"rendered":"\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u3068\u4e73\u764c\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p>\u764c\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3\uff23\u6cbb\u7642\u304c\u518d\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8d85\u4e00\u6d41\u79d1\u5b66\u8a8c\u3067\u3042\u308bNature Review Cancer\u306b\u304a\u3044\u3066\u3082\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u6cbb\u7642\u306b\u3064\u3044\u3066\u306e\u7dcf\u8aac\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Nat Rev Cancer. 2019 May;19(5):271-282. doi: 10.1038\/s41568-019-0135-7. <a href=\"https:\/\/www.nature.com\/articles\/s41568-019-0135-7\" target=\"_blank\" rel=\"noreferrer noopener\">Targeting cancer vulnerabilities with high-dose vitamin C <\/a> Bryan Ngo, Justin M Van Riper, Lewis C Cantley, Jihye Yun<\/p>\n\n\n\n<p>\u8840\u4e2d\u30d3\u30bf\u30df\u30f3C\u6fc3\u5ea6\u3092\u70b9\u6ef4\u306b\u3088\u3063\u3066\u4e00\u5b9a\u4ee5\u4e0a\u306b\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u904e\u9178\u5316\u6c34\u7d20\u3092\u751f\u6210\u3001\u6b63\u5e38\u7d30\u80de\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u305a\u306b\u304c\u3093\u7d30\u80de\u306e\u6838\u3092\u6fc3\u7e2e\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u7d30\u80de\u306e\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u30a2\u30e1\u30ea\u30ab\u306e\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240(NIH)\u3001 \u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc(NCI)\u3001 \u98df\u54c1\u85ac\u54c1\u5c40(FDA)\u306e\u7814\u7a76\u8005\u304c\u5171\u540c\u3067\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u7642\u6cd5\u304c\u304c\u3093\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u30a2\u30e1\u30ea\u30ab\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981(PNAS)\u306b\u767a\u8868\u3057\u3066\u3044\u307e\u3059\u3002\u5404\u7a2e\u306e\u764c\u306b\u304a\u3051\u308b\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3\uff23\u6cbb\u7642\u306e\u81e8\u5e8a\u7814\u7a76\u3082\u4e16\u754c\u4e2d\u3067\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u7d50\u679c\u306e\u5831\u544a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color\"><strong>\uff1c\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u3068\u4e73\u764c\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\uff1e<\/strong><\/p>\n\n\n\n<p>2020\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u30a4\u30bf\u30ea\u30a2\u304b\u3089\u306e\u7dcf\u8aac(review)\u3092\u8981\u7d04\u3057\u3066\u307f\u307e\u3059\u3002<\/p>\n\n\n\n<p>\uff0a\u7dcf\u8aac\uff1a\u3053\u308c\u307e\u3067\u306e\u8ad6\u6587\uff08\u57fa\u790e\u7814\u7a76\u3001\u81e8\u5e8a\u7814\u7a76\u3001\u75c7\u4f8b\u5831\u544a\u306a\u3069\uff09\u3092\u307e\u3068\u3081\u305f\u3082\u306e<\/p>\n\n\n\n<p>\u4e73\u764c\u306b\u5bfe\u3057\u3066\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u304c\u3069\u306e\u3088\u3046\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u3092\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Review<\/p>\n\n\n\n<p><a href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/21\/8397\" target=\"_blank\" rel=\"noreferrer noopener\">Why Vitamin C Could Be an Excellent Complementary Remedy to Conventional Therapies for Breast Cancer\uff1f<\/a><\/p>\n\n\n\n<p>Int J Mol Sci. 2020 Nov 9;21(21):8397. doi: 10.3390\/ijms21218397.<\/p>\n\n\n\n<p>Michela Codini<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u4e73\u764c\u306f\u3001\u4e16\u754c\u3067\u5e74\u9593\uff12\u5104\u4eba\u4ee5\u4e0a\u306e\u65b9\u304c\u767a\u75c7\u3057\u3001\u5973\u6027\u306e\u304c\u3093\u95a2\u9023\u6b7b\u306e\u539f\u56e0\u306e\u7b2c\u4e00\u4f4d\u3067\u3059\u3002\u4e73\u764c\u306e\u767a\u75c7\u539f\u56e0\u306f\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u3001\u30db\u30eb\u30e2\u30f3\u7570\u5e38\u3001\u5bb6\u65cf\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3C\u306f\u3001\u6c34\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306e\u4e00\u3064\u3067\u3059\u3002\u4eba\u9593\u306f\u3001\u30d6\u30c9\u30a6\u7cd6\u304b\u3089\u30d3\u30bf\u30df\u30f3C\u306e\u5408\u6210\u306b\u5fc5\u8981\u306a\u9175\u7d20\u304c\u306a\u304f\u30d3\u30bf\u30df\u30f3C\u3092\u5408\u6210\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u98df\u4e8b\u304b\u3089\u30d3\u30bf\u30df\u30f3C\u3092\u6442\u53d6\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u30d3\u30bf\u30df\u30f3C\u306e\u5316\u5b66\u540d\u306f\u3001\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u3067\u3001\u751f\u4f53\u5185\u3067\u306f\u901a\u5e38\u9084\u5143\u578b\u306eL\uff0d\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u307e\u305f\u306f\u9178\u5316\u578b\u306eL\uff0d\u30c7\u30d2\u30c9\u30ed\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u306e\u5f62\u3067\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3C\u306f\u5f37\u529b\u306a\u6297\u708e\u75c7\u4f5c\u7528\u3068\u514d\u75ab\u7cfb\u3092\u6d3b\u6027\u5316\u3057\u3001\u816b\u760d\u306e\u5897\u6b96\u3001\u8840\u7ba1\u65b0\u751f\u3001\u8ee2\u79fb\u3001\u6cbb\u7642\u3078\u306e\u62b5\u6297\u6027\u3092\u6291\u5236\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u816b\u760d\u8840\u7ba1\u65b0\u751f\u3001\u764c\u306e\u8ee2\u79fb\u6d3b\u6027\u3001\u304a\u3088\u3073\u764c\u7d30\u80de\u5897\u6b96\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u56e0\u5b50\u306e\u3072\u3068\u3064\u304c\u4f4e\u9178\u7d20\u5fae\u5c0f\u74b0\u5883\u3067\u3059\u3002\u816b\u760d\u5185\u306e\u4f4e\u9178\u7d20\u75c7\u306e\u539f\u56e0\u3068\u306a\u308bHIF-1\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u306e\u6297\u816b\u760d\u4f5c\u7528\u306e\u6a19\u7684\u3067\u3059\u3002HIF-1\u306f\u3001\u764c\u60a3\u8005\u306e\u4e3b\u306a\u6b7b\u56e0\u3067\u3042\u308b\u764c\u7d30\u80de\u306e\u8ee2\u79fb\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u30d3\u30bf\u30df\u30f3C\u306f\u3001HIF-1\u306e\u5206\u89e3\u306b\u5fc5\u8981\u306a\u56e0\u5b50\u3067\u3042\u308a\u3001\u30d3\u30bf\u30df\u30f3\uff23\u304c\u764c\u7d30\u80de\u306e\u8ee2\u79fb\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3C\u306fTET\u9175\u7d20\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059\u3002TET\u306f\u7d30\u80de\u3092\u518d\u30d7\u30ed\u30b0\u30e9\u30e0\u3057\u3001\u7d30\u80de\u306e\u6210\u9577\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u751f\u7406\u5b66\u7684\u306b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002 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has-medium-font-size\">\u30fb\u304c\u3093\u306e\u624b\u8853\u3092\u5f85\u6a5f\u4e2d\u306e\u65b9<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-medium-font-size\">\u30fb\u304c\u3093\u306e\u624b\u8853\u5f8c\u306b\u518d\u767a\u3092\u4e88\u9632\u3057\u305f\u3044\u65b9<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-medium-font-size\">\u30fb\u6297\u764c\u5264\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u4f75\u7528\u3057\u3066\u53d7\u3051\u305f\u3044\u65b9<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-medium-font-size\">\u30fb\u6297\u764c\u5264\u306e\u526f\u4f5c\u7528\u304c\u3064\u3089\u3044\u65b9<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-medium-font-size\">\u30fb\u304c\u3093\u3084\u75c5\u6c17\u3092\u4e88\u9632\u3057\u3066\u3001\u5065\u5eb7\u3067\u7f8e\u3057\u3044\u4eba\u751f\u3092\u9001\u308a\u305f\u3044\u65b9<\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-medium-font-size\">\u30fb\u3054\u5bb6\u65cf\u306b\u304c\u3093\u306b\u304b\u304b\u3063\u305f\u4eba\u304c\u3044\u308b\u65b9\u3084\u5e74\u9f62\u7684\u306b\u304c\u3093\u304c\u5fc3\u914d\u306a\u65b9<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u764c\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3\uff23\u6cbb\u7642\u304c\u518d\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u307e\u3059\u3002 \u8d85\u4e00\u6d41\u79d1\u5b66\u8a8c\u3067\u3042\u308bNature Review Cancer\u306b\u304a\u3044\u3066\u3082\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u6cbb\u7642\u306b\u3064\u3044\u3066\u306e\u7dcf\u8aac\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002 Nat Rev Cancer. 20 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[3,4,5,10,131,36,132],"class_list":{"0":"post-210","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-uncategorized","7":"tag-3","8":"tag-4","9":"tag-5","10":"tag-10","11":"tag-131","12":"tag-36","13":"tag-c"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/posts\/210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/comments?post=210"}],"version-history":[{"count":2,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/posts\/210\/revisions"}],"predecessor-version":[{"id":213,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/posts\/210\/revisions\/213"}],"wp:attachment":[{"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/media?parent=210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/categories?post=210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ninomiyacl.com\/blog\/wp-json\/wp\/v2\/tags?post=210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}